Tirzepatide is an injectable medication which, when used in combination with diet and exercise is an extremely effective medical weightloss medication. Tirzepatide belongs to a class of medications called glucagon-like peptide-1 (GLP-1) agonists and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, which mimic the hormone GLP-1 in your body to lower blood sugar levels after eating. Even if you are not diabetic or have insulin resistance Tirzepatide has been shown to melt fat and contributes to incredible weight loss! This mechanism also targets areas in the brain that regulate appetite and food intake. Because of the combination of two peptides over other GLP-1 aganoist peptides it has had the most effective and profound weight loss results, considerably higher than even Semaglutide.
Glucagon-like peptide 1 (GLP-1) is a hormone that causes dramatic effects on the regulation of blood sugar by stimulating glucose-dependent insulin secretion. Insulin is a hormone that promotes sugar uptake by the cells, stores sugar as glycogen, promotes the building of fat, and signals the body to build skeletal muscle. In addition, GLP-1 inhibits glucagon release (which slows down the release of sugar into the blood so that you burn more fat), slow down gastric emptying (makes you feel fuller longer), and suppresses appetite.
Tirzepatide acts in the following ways:
● Delays how quickly our stomachs digest food. Leading to a feeling of fullness and satisfaction with smaller meal sizes.
● Slows intestinal motility so you will feel fuller longer after meals.
● Dual action receptor allows for lower blood sugars, in part by reducing the production of sugar in the liver.
● Stimulates insulin secretion by the pancreas.
● GIP increases energy expenditure, resulting in weight loss reductions
GLP-1 agonists like Tirzepatide help to control blood sugar, but those taking them also tend to lose weight. GLP-1, the key hormone involved, slows down how fast your stomach empties food. In addition to causing the pancreas to release insulin, Semaglutide blocks the hormone that signals the liver to release sugar. Together, these functions help you feel less hungry, eat less, and lose weight.
All patients start on the lowest dose of Tirzepatide at 2.5mg (25U) injected subcutaneously into belly fat once weekly. Patients increase 2.5mg (25U) monthly if well tolerated (slower if nauseous or gi upset), up to a total of 15mgs (150U). The longterm weightloss in the clinical trials without diet and exercise modification was phenomenal.
You will slowly work your way up to the target dose at which time you will see the greatest weight loss. This was the case in clinical trials, where participants had their dose adjusted until they reached 15mg (or 150U) once weekly. It is important to keep in mind that weight loss takes time, and you’ll see the best results when you are using Tirzepatide in combination with healthy diet and exercise. Although rare, some medications may not work for you or you may not tolerate the maximum dose.
No, Tirzepatide is not a type of insulin or a substitute for insulin. Tirzepatide does stimulate your pancreas to release insulin when glucose (sugar) IS present. Tirzepatide relies upon your body’s own insulin production for this effect, Tirzepatide isn’t used when your pancreas is no longer making insulin such as type 1 diabetics.
No, Tirzepatide is not a stimulant. While other weight loss medications, like phentermine, have stimulating effects that help curb your appetite, Tirzepatide works differently (see above).
Yes. Tirzepatide is considered to be safe and effective when used as prescribed. But safe doesn’t mean without risks. Tirzepatide also carries a boxed warning about thyroid C-cell tumors occurring in rodent studies (with unknown risks in humans). Tirzepatide shouldn’t be used if you or your family have a history of certain thyroid cancers. Tirzepatide should not be used if you are taking other blood sugar medications.
No. Tirzepatide is not typically covered by insurance for those who are not type two diabetics.
The most common side effects include nausea and constipation. * Patients also report acid reflux, stomach pain,
vomiting, and diarrhea. The risk of serious side effects increases in patients with hypoglycemia, kidney
problems, and risk of allergic reactions.
*500mcg/mL of Cyanocobalamin added to reduce nausea side effects.
RISK OF THYROID C−CELL TUMORS. If you or any family members have been diagnosed with Multiple Endocrine Neoplasia Syndrome Type 2 or Medullary thyroid cancer you should not take Tirzepatide. If you have ever had pancreatitis consult with your medical provider as using Tirzepatide can increase the risk of developing pancreatitis.